Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging - Centre Georges Francois Leclerc Accéder directement au contenu
Article Dans Une Revue ACS Omega Année : 2019

Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging

Isabelle Séverin

Résumé

Superparamagnetic iron oxide nanoparticles were developed as positron emission tomography (PET) and magnetic resonance imaging (MRI) bimodal imaging agents. These nanoparticles (NPs), with a specific nanoflower morphology, were first synthesized and simultaneously functionalized with 3,4-dihydroxy-l-phenylalanine (LDOPA) under continuous hydrothermal conditions. The resulting NPs exhibited a low hydrodynamic size of 90 ± 2 nm. The functional groups of LDOPA (-NH2 and -COOH) were successfully used for the grafting of molecules of interest in a second step. The nanostructures were modified by poly(ethylene glycol) (PEG) and a new macrocyclic chelator MANOTA for further ⁶⁴Cu radiolabeling for PET imaging. The functionalized NPs showed promising bimodal (PET and MRI) imaging capability with high r2 and r2∗ (T2 and T2∗ relaxivities) values and good stability. They were mainly uptaken from liver and kidneys. No cytotoxicity effect was observed. These NPs appear as a good candidate for bimodal tracers in PET/MRI.
Fichier principal
Vignette du fichier
2019 acsomega.8b03283.pdf (7.57 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-02068644 , version 1 (08-03-2021)

Identifiants

Citer

Guillaume Thomas, Julien Boudon, Lionel Maurizi, Mathieu Moreau, Paul Walker, et al.. Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging. ACS Omega, 2019, 4 (2), pp.2637-2648. ⟨10.1021/acsomega.8b03283⟩. ⟨hal-02068644⟩
254 Consultations
112 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More