Microvilli-derived Extracellular Vesicles Govern Morphogenesis in Drosophila wing epithelium

Ilse Hurbain (1) , Anne-Sophie Macé , Maryse Romao , Lucie Sengmanivong , Laurent Ruel , Renata Basto , Pascal P Thérond , Graça Raposo , Gisela D’angelo

1 Centre de recherche de l'Institut Curie [Paris]

The regulation and coordination of developmental processes involves the secretion of morphogens and membrane carriers, including extracellular vesicles, which facilitate their transport over long distance. The long-range activity of the Hedgehog morphogen is conveyed by extracellular vesicles. However, the site and the molecular basis of their biogenesis remains unknown. By combining fluorescence and electron microscopy combined with genetics and

Domaines: Sciences du Vivant [q-bio]

Ilse Hurbain, Anne-Sophie Macé, Maryse Romao, Lucie Sengmanivong, Laurent Ruel, et al.. Microvilli-derived Extracellular Vesicles Govern Morphogenesis in Drosophila wing epithelium. 2021. ⟨hal-03455269⟩